Sicilian Gambit Classification

An alternative classification system, known as the 'Sicilian Gambit', has recently been proposed that is based on arrhythmogenic mechanisms.

• This system identifies one or more 'vulnerable parameters' associated with a specific arrhythmogenic mechanism.

  • A vulnerable parameter is an electrophysiological property or event whose modification by drug therapy will result in the termination or suppression of the arrhythmia with minimal undesirable effects on the heart.

• Unlike the Vaughan Williams classification system, this system can readily accommodate drugs with multiple actions.

• This multidimensional classification system is significantly more complex than the standard Vaughan Williams system, but provides a more flexible framework for classifying antiarrhythmic drugs based on pathophysiological considerations.

Category: Pharmacology Notes