Antiarrhythmic Actions of Antiarrhythmic Drugs
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| Drug (Class) | Class I Actions | Class II Actions | Class III Actions | Class IV Actions | Other Actions |
| Quinidine (IA) | ++ | + | ++ | + | Alpha-adrenergic blockade |
| Procainamide (IA) | +++ | + | + |
| Ganglionic blockade |
| Disopyramide (IA) | +++ |
| + | + | Anticholinergic |
| Lidocaine (IB) | +++ |
|
|
|
|
| Mexiletine (IB) | +++ |
|
|
|
|
| Tocainide (IB) | +++ |
|
|
|
|
| Phenytoin (IB) | + | + |
| + |
|
| Encainide (IC) | +++ |
|
|
|
|
| Flecainide (IC) | +++ |
| + | + |
|
| Propafenone (IC) | ++ | + |
| + |
|
| Moricizine (I) | ++ |
|
|
|
|
| Propranolol (II) | + | +++ |
|
|
|
| Esmolol (II) | + | +++ |
|
|
|
| Sotalol (II/III) |
| ++ | +++ |
|
|
| Amiodarone (III) | +++ | + | ++ | + | Alpha-adrenergic blockade |
| Ibutilide (III) |
|
| +++ |
|
|
| Bretylium (III) |
| ++ | ++ |
| Sympathomimetic |
| Verapamil (IV) | + | + |
| ++++ |
|
| Diltiazem (IV) |
|
|
| +++ |
|
| Adenosine (Misc.) |
| + |
| ++ | Enhances potassium conductance Inhibits cAMP-induced Ca++ influx |
Category: Pharmacology Notes
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