Methicillin resistance in S. aureus
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You are here: Home » Microbiology Notes » Methicillin resistance in S. aureus
first noted in 1970
70% of clinical isolates are methicillin-resistant Staph. aureus (MRSA) and 50% of community isolates are MRSA
forces us to use vancomycin, linezolid, Synercid
reason for resistance is mecA, which encodes PBP2a (penicillin-binding protein 2A), which has a low affinity for β-lactam antibiotics
genotypically diverse. MRSA arose multiple times and have spread dramatically
approaching 70%
PBP2a encoded by mecA gene in MRSA PDF 21
co-crystal structure with β-lactam ring was identified; methicillin has trouble getting itself all the way into the active site
Category: Microbiology Notes
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