Innate immunity: pattern recognition receptors

on 7.9.08 with 0 comments



  • recognizes molecules unique to microorganisms rather than human cells

  • our body has evolved ways to recognize these molecules and to activate immune system function upon their recognition

  • however, this cannot differentiate pathogen from non-pathogen—for example, every Gram-negative bacterium, pathogenic or not, all have a Gram-negative cell wall

  • molecles include

    • LPS of Gram-negative cell wall

    • peptidoglycan and lipotechoic acid in Gram-positive cells

    • mannose-rich glycans of microbial glycolipids

    • flagellin

    • pilin

    • fungal cell wall

Category: Microbiology Notes

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