Cathelicidins
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You are here: Home » Microbiology Notes » Cathelicidins
mouse genetics are a powerful tool
it was discovered that frog mucus has small, cationic peptides that keep frog free from pond scum infection
these were also discovered in mammals and are now termed cathelicidins
fortunately for mice and humans, one cathelicidin dominates
these are produced by epithelial surfaces and granulocytes
in normal skin, there is almost no cathelicidin. if skin is injured, cathelicidins are produced
cathelicidin-knockout mice had difficulty controlling infection
the signature feature of many microbial pathogens is that they repel, pump out, degrade, bind, neutralize our natural antimicrobial peptides
Category: Microbiology Notes
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