Giant cell tumor (Quasimalignant)

-Is a neoplasm that originates from non-bone forming supportive connective tissue of the marrow. Contains multiple nucleated giant cells

1. Clinical Features

   1. Males:

      1. Tumor tends to be malignant

   2. Females:

      1. Tumor tends to be benign

   3. 80% are benign, 60% are lytic

2. Key Radiologic features

   1. Most lesions begin in metaphysis and extend to subarticular location.

   2. Thin, expanded cortex, which gives the Soap Bubble Pattern in 40%

   3. May have delicate periosteal reaction.

   4. M/c in distal femor and proximal tibia

3. Most worrisome complication

   1. 20% of the time could be malignant

Category: Orthopedics Notes , Tumors Revision