Immunity to fungi

on 23.5.08 with 0 comments



For elimination of fungi, the innate arm of the immune response is more efficient. The innate response involves: chemotactic factors, chemokines and other chemicals that lure inflammatory cells to the site of infection, macrophages erode the infection. Adaptive immunity is complex. T cells get activated, and secrete macrophage activating cytokines, activated macrophages phagocytose the fungal infection. Meanwhile, differentiated B cells produce antibodies to fungal toxins. Spores produced by fungi bind to IgE – this degranulates the mast cell – histamine is released. Histamine vasodilates vessels, increase fluid flow – wash out spores.

Category: Pathology Notes

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