NSAIDs don’t produce many of the side effects as the opiates and are not addictive. From a graph measuring relief from severe cancer pain, 225mg Ketoprofen (an NSAID available otc) is comparable to intramuscular (injection) morphine (10mg).
Here’s the issue, one drug is acting on the opiate receptor, another is acting as a COX-1, COX-2 inhibitor, and yet the analgesic effect on severe cancer pain is the same. So why use an opiate instead of an NSAID?
The opiate drugs give you the added euphoria that NSAIDs don’t. So analgesia is one thing, but how the pt feels is important.
Category:
Pharmacology Notes
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