General Anesthetics: SEVOFLURANE

-NEWEST agent (1995)

-similar structure to desfluane, but CF3 attached to central C; has 7 F-s

-low Oswald coefficient= 0.69, similar to desflurane and nitrous oxide

-fast induction and emergence, highly controllable

-NON-PUNGENT, NON-IRRITATING, GOOD INDUCTION; used with kids!

-more potent than desflurane (MAC= 2%)

-cardiac output maintained by decreased TPR

-good muscle relaxer

-less stable than desflurane, maetabolism 100x greater than desflurane (2%)!!! And is less chemically stable!

-one metabolic product is “compound A” which is LETHAL TO RATS AT CLINICALLY USEFUL CONCENTRATIONS!! Toxic to liver and kidneys, and can damage DNA!

-degraded by soda lime (CO2 absorber in breathing circuit)

-main advantages: lack of pungency, speed, controllability

Category: Pharmacology Notes