Benzodiazepines: Effects on Pregnancy
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Benzodiazepines (and their metabolites) can freely cross the placental barrier and accumulate in fetal circulation
Administration during the first trimester can result in fetal abnormalities
Administration in third trimester (close to the time of birth) can result in fetal dependence, or “floppy-infant syndrome”
Benzodiazepines are also excreted in the breast milk
Category: Pharmacology Notes
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