Porphyria Cutanea Tarda (P.C.T.)
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27.2.08
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You are here: Home » Dermatology Notes » Porphyria Cutanea Tarda (P.C.T.)
Photodistributed blisters, crusts and erosions that lead to scars and pigmentary changes. May be associated with milia, hypertrichosis and sclerodermoid changes.
Diagnosis
Clinical suspicion confirmed by urine or serum porphyrins.
Pathology
May be associated with viral hepatitis, hormonal therapies, hemodialysis or alcohol intake. Etiology is a defect in the uroporphyrinogen decarboxylase enzyme used in the production of heme.
Principles of Therapy
Complete sun protection extremely important. Treatment of underlying disorder. Phlebotomy and low-dose antimalarials (hydroxychloroquine) are treatment options.
Tags: Porphyria, Phelbotomy
Category: Dermatology Notes
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