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Pharmacology of the Eye
“The eye is a good example of an organ with multiple ANS functions, controlled by several different autonomic receptors.” (Katzung)
Increased intraocular pressure: Untreated -> blindness
Glaucoma:
- Open-angle (wide, chronic) – treated with betablockers and other agents
- Closed-angle (narrow-angle) – dilated iris can occlude outflow. Pilocarpine or surgical removal of part of iris (iridectomy)
Glaucoma treatment
- a-Agonist: Increase Outflow
- M-Agonists: Increase Outflow
- b -Blocker: decrease Secretion
- a2-Agonist: decrease Secretion
- Prostaglandins: Increase Outflow
- Carbonic acid inhibitors: Decrease Secretion
Category:
Ophthalmology Notes
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