Composition of Pancreatic Juice and Regulation of Secretion

1. Composition of Pancreatic Juice
1. 1.2 - 1.5 liters per day
2. water and electrolytes (mainly bicarbonate ions)
3. enzymes - precursors and active digestive forms
• trypsinogen -----------------> trypsin
• enterokinase
• procarboxypeptidase --------------> carboxypeptidase
• chymotrypsinogen -------------> chymotrypsin
• trypsin
• amylase (carbohydrates), lipases (fats), nucleases (nucleic acids)
  
2. Regulation of Pancreatic Secretion
1. parasympathetic - causes release during cephalic and gastric phases of gastric secretion
2. secretin - hormone that causes release of "bicarbonate-rich" pancreatic juices in response to the presence of HCl
3. cholecystokinin - hormone that causes release of "enzyme-rich" pancreatic juice in response to the presence of proteins and fats

Category: Physiology Notes