MINIMAL CHANGE (Robbins pp 954)
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General: a.k.a: nil disease, lipoid nephrosis. Causes: Nephrotic syndrome.
Epidemiology/At risk individuals: Risk individuals: 2-6 year old children with respiratory tract infection or recent immunisation. 65% of nephrotic syndrome in children.
Clinical features/course: selective proteinuria (albumin related). The visceral epithelium is injured ≫ loss of polyanions ≫ proteins (-ve charge) are allowed through.
Morphology: LM: Glomeruli: normal. EM: Glomeruli: normal, FM: loss of podocyte processes due to injury. IF: -ve.
Management: corticosteroids
Category: Pathology Notes
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