Antipsychotics
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Typical Antipsychotics: Blockers of Dopamine D2 Post-synaptic Receptors
Phenothiazines – chlorpromazine, fluphenazine, trifluoperazine, thioridazine
Chlorpromazine α1 = 5-HT2 > D2 > D1
Thioxanthines – chlorprothixene, thiothixene
Butyrophenones – haloperidol, droperidol
Haloperidol: D2 > D1 = D4 > α1 > 5-HT2
Others – loxapine, molindone, pimozide
Atypical Antipsychotic Drugs: Lower relative blockade of D2 receptors, no or low EPS
Clozapine Antagonizes D4 = a1 > 5HT2 > D2 = D1; no EPS; agranulocytosis and seizure in 2% of patients
Risperidone D2 and 5HT2 antagonist; antipsychotic > EPS
Olanzapine Most like clozapine in receptor profile, S2 > D2, high M1 and D1 receptor blockage
Quetiapine Similar to clozapine, S2 > D2
Sertindole: Similar to resperidone (5HT and DA antagonist) also a1 antagonist.
Category: Pharmacology Notes
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