Adverse Pharmacologic Effects of Antipsychotic Drugs
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| Type | Manifestations | Mechanism |
| Autonomic nervous system | Loss of accommodation, dry mouth, difficulty urinating, constipation Orthostatic hypotension, failure to ejaculate Hypotension, arrhythmia | Muscarinic cholinoceptor blockade Alpha adrenoceptor blockade Antiadrenergic |
| Central nervous system | Parkinson’s syndrome, acute akathisia, acute dystonia Tardive dyskinesia, tardive dystonia Toxic-confusional state Sedation | Dopamine receptor blockade (Acute) Supersensitivity of dopamine receptors (Chronic) Muscarinic blockade Antihistaminergic (H1) |
| Endocrine system | Amenorrhea-galactorrhea, infertility, impotence | Dopamine receptor blockade resulting in hyperprolactinemia |
| Miscellaneous | Neuroleptic malignant syndrome Photosensitivity, heat sensitivity, cholestatic jaundice, retinal pigmentation | |
Category: Pharmacology Notes
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