DNA Synthesis Inhibitors
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Quinolones – Nalidixic acid, Cinoxacin
Fluoroquinolones – Norfloxacin, Ciprofloxacin, Ofloaxacin, Levofloxacin
Mechanism of action: Inhibit DNA gyrase mediated supercoiling.
Contraindications: Pregnancy and young children due to cartilage problems; NOT USEFUL IN TREATING C. DIFFICILE.
Indications: UTIs (nalidixic acid and cinoxacin), general bacterial infections (norfloxacin), bone and soft tissue infections caused by staphylococci and gram(-) organisms (ciprofloxacin, ofloxacin, levofloxacin).
Urinary Antiseptics
Nitrofurantoin – Used for treatment of UTIs; contraindicated in severe renal insufficiency; vomiting is most common side effect.
Category: Pharmacology Notes
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