Antileprosy Drugs
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Dapsone – Sulfa drug; adjunct therapy with corticosteroids, aminoglycosides, or antimalarials may be helpful; can cause anemia and methemoglobinemia.
Amithiazone – Greater effect on tuberculoid form than on lepromatous form; substitute for patients intolerant of sulfones.
Clofazamine – Substitute; discoloration of the skin.
Rifampin – Hepatitis and inhibits metabolism of 35 drugs.
Thalidomide – Highly effective.
Ethionamide
Tx of M. avium complex – Rifabutin, macrolides, quinolones, clofazimine, amikacin.
Category: Pharmacology Notes
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