Echinocandin
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Caspofungin (most recently approved antifungal – Jan 2001)
Mechanism of action: inhibits beta (1,3)-D-glucan synthesis, blocking cell wall synthesis
Absorption: poor; highly protein; administered IV
Uses: active against a number of fungi, but particularly effective against invasive candidiasis and aspergillosis (promising new alternative to amphotericin) via once daily IV administration; no activity against cryptococcus
Adverse effects: fever, nausea, vomiting, flushing; some irritation at inj site; small elevation of liver enzymes
Tags: Caspofungin, cryptococcus
Category: Pharmacology Notes
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