Allylamines
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Naftifine and Terbinafine
Mechanism of action: inhibits fungal squalene metabolism
increased levels of squalene are toxic to fungi; also reduces ergosterol
Uses: effective for most cutaneous mycoses either topically (eg. tinea corporis
and tinea cruris) or, in the case of terbinafine, orally for nail infections (90% cure rate, without side effects)
[not effective against Candida]
Tags: Naftifine, Terbinafine
Category: Pharmacology Notes
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