Chemical Structures of Local Anesthetics
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The Local Anesthetics, unlike the general anesthetics, have a definite structure/ function relationship. The amines are molecules based on nitrogen. Each can be protonated to get a positive “+” charge (except the quaternary form, which has a permanent “+” charge), making them weak bases.
BH+ B + H+ -NH+ -N + H+
The carboxyl groups are weak acids.
AHA- + H+ -COOH -COO- + H+
Category: Pharmacology Notes
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