The Thiazolidinedione class includes Rosiglitazone (Avandia) and Pioglitazone (Actos). Given the action of metformin and the sulfonylureas, you can combine the agents for useful effects. Combination therapy with insulin and sulfonylurea may be a more appropriate and a suitable option to insulin monotherapy in subjects with non-insulin-dependent diabetes in whom primary or secondary failure of sulfonylurea developed. Approximately 50% of diabetic pts may lose adequate metabolic control using oral agents after 10 years, primarily because of relative insulin deficiency and continuing insulin resistance.
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Pharmacology Notes
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