Dental considerations in the Diabetic
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6.12.05
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Corticosteroids may increase glucose levels. High doses of salicylate analgesics (aspirin et al.) and certain NSAIDs (especially Ibuprofen and Naproxen) increase hypoglycemic action.
Type 1 diabetics are at risk for leukopenia, thrombocytopenia, delayed wound healing,
- increased risk of infection, hypo-hyperglycemic episodes, angioapathy, neuropathy, retinopathy, platelet hyperaggregability, periodontal disease, and gingival bleeding. Beta-blockers may mask sings of hypoglycemia. Alcohol enhances insulin action.
Oral antidiabetic agents (OAAs)
In Type 2 diabetics: glucocorticoids may increase glucose, beta-blockers may inhibit
- insulin release, salicylates and some NSAIDs cause serum protein displacement of OAA’s, leading to hypoglycemia, antabuse type reaction with alcohol, metformin and pheformin cause elevated lactoate (lactic acidosis), sulfur-containing OAA’s, weight loss reduces OAA dose needs, and hyperinsulinemia may be present.
Category: Pharmacology Notes
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