Leukopoiesis and Colony Stimulating Factors (CSFs)

1. Leukopoiesis - the production, differentiation, and development of white blood cells; all cells derived from hemocytoblast

   Myeloid stem cell-> lymphocyte stem cell-> myeloblast-> monoblast-> lymphoblast-> promyelocyte-> promonocyte-> prolymphocyte->

   a. myelocyte-> MONOCYTE-> LYMPHOCYTE->

   b. metamyelocyte-> (macrophages) (plasma cell)

   c. band cell-> (3 month lifespan) (days-decades lifespan)

   EOSINOPHIL }

   NEUTROPHIL } (0.5 to 9 day lifespan)

   BASOPHIL }

2. Colony Stimulating Factors (CSF) - hematopoietic hormones that promote leukopoiesis

produced by Macrophages and T lymphocytes

1. macrophage-monocyte CSF (M-CSF)
2. granulocyte CSF (G-CSF)
3. granulocyte-macrophage CSF (GM-CSF)
4. multi CSF (multiple lymphocyte action)
5. interleukin 3 (IL-3) (general lymphocytes)

Category: Pathology Notes