1. Although the pathogenesis ofatherosclerosis is unclear, name the lesion that may represent the earliest morphologic stage of a plaque.
Answer; The earliest morphologic stage of an atherosclerotic plaque is most likely the fatty streak.
2. Describe the "complicated" plaque found in atherosclerosis.
Answer: The complicated plaque found in atherosclerosis may be characterized by ulceration, calcification, hemorrhage, thrombosis, and the development of an aneurysm.
3. Of what is the "porridge-like" material composed?
Answer; The "porridge like" material is composed of lipid material.
4. Describe the proposed role of serum lipoproteins in the pathogenesis of human atherosclerosis.
Answer: There appears to be a direct correlation of the level of LDL cholesterol and atherosclerotic heart disease and in inverse correlation of the level ofHDL cholesterol and athterosclerotic heart disease.
5. List some complications ofatherosclerosis.
Answer: Complications of atherosclerosis include myocardial infarction, cerebrovascular accidents (strokes), aneurysms, gangrene of the lower extremities and mesenteric infarction.
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