Recommendations for the simultaneous administration of antiretroviral drugs with rifampin or rifabutin

Recommendations for the simultaneous administration of antiretroviral drugs with rifampin or rifabutin

Drug

With rifabutin

With rifampin

Comments

Saquinavir

Hard gelatin capsules

Soft gelatin capsules

Possible, if ritonavir is included in the regimen.

Probable

(dose: rifabutin 600 mg qd or 2-3 times/week) or 150 mg qd or 2-3 times/week.

Possible, if ritonavir is included in the regimen.

Possible, if ritonavir is included in the regimen.

Pharmacokinetic data and clinical experience are limited. (dose: saquinavir 400 mg bid + ritonavir

400 mg bid)

Pharmacokinetic data and clinical experience are limited.

The co-administration of saquinavir + rifampin is not recommended without ritonavir.

Ritonavir

Probable (rifabutin: 150 mg 2-3 times/week)

Probable

Pharmacokinetic data and clinical experience on the co-administration of ritonavir + rifampin are limited.

Indinavir

Yes

No

Clinical data are limited but favourable.

(dose indinavir: 800 mg tid or 1000 mg tid + rifabutin 150 mg qd or 300 mg 2-3 times per week).

Nelfinavir

Yes

No

Clinical data are limited but favourable.

(dose nelfinavir: 750 mg tid or 1250 mg bid or

1000 mg tid + rifabutin 150 mg qd or 300 mg 2-3 times per week).

Amprenavir

Yes

No

No clinical experience, but should be possible with the normal dose of rifabutin.

Nevirapine

Yes

No

No published clinical experience. The combination would be possible with the normal dose of rifabutin.

Delavirdine

No

No

Efavirenz

Probable

The combination is possible. (rifabutin: 450 mg or 600 mg qd, or 600 mg

2-3 times/week).

Probable.

The combination is possible with the normal dose of rifampin + efavirenz

600 mg or 800 mg qd.