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when a cell is injured (alcohol, starvation, radiation, viral infection, autoimmunity), cell function (which can be measured biochemically) decreases rapidly
as function decreases, cell death or adaptation occurs
the rate of loss of ability to grow (i.e., the rate of death) occurs faster than any other changes
after a cell has died, you see ultrastructural changes (nuclear chromatin, lysosomes, polyribosomes)
then, you see light microscopic changes
so when a cell is dead, you won’t see any evidence with light microscopy until about six hours after death
gross morphologic changes occur only, say, after two days
Category: Medical Subject Notes , Pathology Notes
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