Hematopoietic growth factors

• Stem cell factors (c-kit ligand, flt3-ligand) – stimulate production of pluripotent stem cells

• EPO (erythropoietin)

  • Made by kidneys and liver

  • Stimulates erythropoiesis and megakaryocytopoiesis (problems with EPO will be manifested as RBC and platelet changes)

• GM-CSF (granulocyte/monocyte colony stimulating factor)

  • Made by T cells and stimulated by fibroblasts, monocytes, and endothelial cells

  • Stimulates formation of granulocytes and monocytes from G/M-CFU

• Interleukins

  • Hematopoietic cofactors from monocytes, lymphocytes, fibroblasts, and endothelial cells

  • IL-3 stimulates CFU-S (the myeloid stem cell)

  • IL-5 stimulates CFU-Eo (eosinophil stem cells)

• Thrombopoietin – regulates megakaryocytopoiesis

Category: Medical Subject Notes , Pathology Notes