Budd-Chiari syndrome

on 17.3.09 with 0 comments




  • thrombosis of hepatic vein

  • hepatomegaly

    • ascites

    • abdominal pain

    • liver dysfunction

    • sometimes, acute liver failure

Pathology

  • thrombi in large hepatic veins

  • hemorrhage along the central veins

  • liver necrosis

  • may evolve into cirrhosis

Grossly

  • thrombosed hepatic vein

Histology

  • you see bleeding into the space of Disse, the sinusoidal plates

  • you also see sinusoidal congestion

Pathogenesis

  • most commonly, hypercoagulable states: polycythemia vera, factor V Leiden, oral contraceptives, pregnancy, systemic malignancy

  • stasis or mass lesions and vascular injuries, much like Virchow’s triad











Category: Medical Subject Notes , Pathology Notes

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