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thrombosis of hepatic vein
hepatomegaly
ascites
abdominal pain
liver dysfunction
sometimes, acute liver failure
Pathology
thrombi in large hepatic veins
hemorrhage along the central veins
liver necrosis
may evolve into cirrhosis
Grossly
thrombosed hepatic vein
Histology
you see bleeding into the space of Disse, the sinusoidal plates
you also see sinusoidal congestion
Pathogenesis
most commonly, hypercoagulable states: polycythemia vera, factor V Leiden, oral contraceptives, pregnancy, systemic malignancy
stasis or mass lesions and vascular injuries, much like Virchow’s triad
Category: Medical Subject Notes , Pathology Notes
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