Recognize the disease specific chromosomal abnormality in CML
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You are here: Home » Medical Subject Notes , Pathology Notes » Recognize the disease specific chromosomal abnormality in CML
The Ph1 (t(9;22) forming bcr-c-abl) is in 90+% of CML (even those without Ph1 will have bcr-c-abl gene)
The 210-kd protein has tyrosine kinase activity (blocked by Gleevec)
Category: Medical Subject Notes , Pathology Notes
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