Neonatal/post-transfusional thrombocytopenia
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You are here: Home » Medical Subject Notes , Pathology Notes » Neonatal/post-transfusional thrombocytopenia
Mediated by Abs against a specific platelet Ag (e.g., Duzo, PL, Bak)
Neonatal
Mom exposed to a fetal platelet Ag she doesn’t have
IgG anti-fetal platelet Abs cross the placenta and destroy the fetus’ platelets
Post-transfusional
This is an anamnestic response to previous sensitization (maybe from transfusion, maybe from pregnancy) to certain platelet Ags that the patient doesn’t have
When given a transfusion, platelets that have said Ag will be coated with Ab and their survival will greatly decrease
Category: Medical Subject Notes , Pathology Notes
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