Subacute combined degeneration (from B12 deficiency)
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You are here: Home » Pathology Notes » Subacute combined degeneration (from B12 deficiency)
Both the ascending and descending tracts of the spinal cord are affected (degeneration of posterior and lateral tracts of the spinal cord white matter)
Disease progression
Early, myelin begins to swell (looks like vacuolar degeneration of AIDS); this is reversible
Later there is a permanent degeneration of axons
Get spastic paresis, sensory ataxia, and paresthesias of the legs
Category: Pathology Notes
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