Secondary Glomerulonephritis

GN could be secondary to systemic diseases. 2 will be mentioned here: SLE and Diabetes

1. SLE --- many glomerular manifestations, divided into 6 stages.

WHO Classification:

1. No damage.

II. Mesangial GN

III. Focal proliferative GN

IV. Diffuse proliferative GN

V. Membranous GN

IV. Chronic GN (this is not a unique type. Rather, this is the end stage of other types of GNs. On light microscopy we’ll see sclerosis, hyalinization of glomeruli.

Note: on EM, IC deposits will be subendothelial.

2. Diabetes

As we all knew even before medical school, one of the most serious sequelae of this disease is renal failure. Often, a patient will have diffuse glomerulosclerosis. This is most frequent, but not specific for diabetes. One could also have nodular glomerulosclerois. This is very characteristic of diabetes. Parts of glomeruli will be hyalinized. This is known as Kimmelstiel-Wilson disease (note: this is something that will probably be tested on exam or on boards, so learn it)

Category: Nephrology Notes , Pathology Notes