Pathology Of Penis

1. Congenital

   1. Hypospadias: urethral opening is on the ventral surface of the penis

   2. Epispadias: urethral opening is on the dorsal surface of the penis

These types of abnormalities can cause obstruction and be the cause of infertility.

3. Phimosis: the orifice of the prepuce is too small to permit its normal retraction. This can lead to infections.

2. Inflammatory processes

These most commonly are related to STDs (herpes, chlamydia, chancroid (H. dycrei), syphilis, etc.). General inlammation of the glans is called balanoposthitis, and could be secondary to Candida infection or infection with anaerobic bacteria.

3. Tumors

Benign:

Condyloma Acuminatum: genital warts, caused by HPV types 6, 11. Histo of condyloma acuminatum would be similar to a regular wart that we studied in derm (hyperkeratosis, acanthosis, koilocytosis, etc. BM is intact, there is no invasion)

Carcinoma in situ:

1. Bowen disease: occurs in men over 35, involves the shaft. It can eventually become invasive. This is associated with presence of carcinoma or carcinoma in situ elsewhere in the body.

2. Erythroplasia of Queryat: involves glans and prepuce. Just like Bowen disease, this one can become invasive.

3. Bowenoid papulosis: younger age of onset than in Bowen disease. Several papular lesions are usually present on the shaft. It rarely becomes invasive. If you had to pick one, this would be the one to get!

Malignant:

Squamous cell carcinoma: very rare, occurs mostly in uncircumcised men, caused by HPV types 16, 18.

Category: Pathology Notes