OPIOIDS - IV
on
15.1.09
with
0 comments
You are here: Home » Pharmacology Notes » OPIOIDS - IV
|
CNS | Agent | Fentanyl | Sufentanil | Alfentanil | Remifentanil |
| Analgesia | Jannsen Hypothesis |
|
| Selective mu | |
| Euphoria |
|
|
|
| |
| Sedation |
|
|
|
| |
| CTZ stim |
|
|
|
| |
| Miosis |
|
|
|
| |
| EEG | Seizure activity | Seizure activity< | Seizure activity |
| |
| Mm rigidity | With large rapid iv |
|
|
| |
| CBF | autoreg |
|
| ↓ | |
| ICP | ↑20 press autoreg | ↑20 press autoreg |
| 0 | |
|
Resp | Vminute | Ion trapping in stomach or reestablish V/Q relationship → late resp depression |
|
|
|
| RR |
|
|
|
| |
| TV |
|
|
|
| |
| Response CO2 | Potent depressant |
|
|
| |
| Cough reflex | Protussive large dose |
|
|
| |
| Ciliary activity |
|
|
|
| |
| Raw |
|
|
|
| |
|
CVS | CO | cardiostable |
|
|
|
| BP | ↓MAP |
|
| ↓ | |
| SVR | minimal |
|
|
| |
| Barorec reflex | ↓↓ |
|
|
| |
| HR | ↓↓ |
|
| ↓ | |
| Contractility |
|
|
|
| |
| Venodilatation |
|
|
|
| |
| Arrhythmias |
|
|
|
| |
| Mechanisms | Profound vagotonic |
|
|
| |
| GIT | Motility |
|
|
|
|
| Gastric empty |
|
|
|
| |
| Biliary spasm | 3 x morphine (3%) |
|
|
| |
| LES tone |
|
|
|
| |
| Mechanism |
|
|
|
| |
|
Renal | Blood flow |
|
|
|
|
| Ureteric peristalsis |
|
|
|
| |
| Detrusor tone |
|
|
|
| |
| Sphincter tone |
|
|
|
| |
| ADH |
|
|
|
| |
| Obste- trics | Uterine tone |
|
|
|
|
| Placental T/F |
|
|
|
| |
|
Side effects | His release | No | No |
|
|
| Other |
|
|
|
| |
| Interactions | Potentiate benzos |
|
|
| |
| Drug dependence | Tolerance |
|
|
|
|
| Dependence |
|
|
|
| |
| Withdrawal |
|
|
|
|
Category: Pharmacology Notes
Subscribe to:
Post Comments (Atom)
POST COMMENT
0 comments:
Post a Comment