MUSCLE RELAXANTS: Drug interactions

on 13.1.09 with 0 comments



1. inhaled anaesthetics

pan, dTC > vec, roc

1) muscle Q (isoflurane)

2) central effect

3)release Ach

4)post synaptic sensitivity


2. antibiotics

- Mg like release Ach

- stabilise post synaptic membrane


3. local anaesthetics

- prejunctional release Ach

- stabilise post synaptic membrane
- directly depress skel m fibres


4. diuretics

- frusemide inhibits cAMP prodnrelease Ach


5. Magnesium

- Ach release
- stabilisation of post synaptic membrane

6. lithium

7. phenytoin

Category: Pharmacology Notes

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