Acute pyelonephritis
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16.1.09
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You are here: Home » Nephrology Notes , Pathology Notes » Acute pyelonephritis
Etiology: gram neg. bacteria, i.e., Proteus, Klebsiella, E. coli that normally reside in the gut (yes, I guess micro is coming back to haunt us already).
Most often, it’s a result of ascending infection from urethra, up the bladder, ureter, pelvis, up into the tubules. Sometimes, pyelonephritis can be caused by hematogenous spread (ex. staph from endocarditis), but it’s rather rare
Clinical symptoms: fever, dysuria, frequency, urgency, costo-vertebral tenderness (patient will report pain when you do a kidney punch).
Histo: PMNs in the tubule, as a response to infection. Eventually PMNs make their way into the interstitum, making damage.
Urine: WBC, organisms, WBC casts.
Category: Nephrology Notes , Pathology Notes
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