Malaria: Severe anaemia

on 8.10.08 with 0 comments



Severe anaemia occurs due to haemolysis (of both parasitised and non-parasitised red blood cells – the latter via immune-mediated mechanisms), due to excessive action of the spleen i.e. hypersplenism (until weeks after the infection), due to possible haemorrhages (low blood platelets, splenic rupture) and due to disturbed production of new blood cells in the bone marrow (dyserythropoiesis), including that due to TNF-α. Malaria pigment interferes with the differentiation of blood cells in the bone marrow and can contribute to the anaemia.

Category: Medicine Notes

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