Malaria: History, staining methods

on 16.10.08 with 0 comments



The study of dyes led to the development of various techniques for staining bacterial preparations and histological sections. Romanovsky stains are based on a mixture of basic dyes (positively charged) such as methylene blue, and anionic dyes (negatively charged), such as eosin. The positively charged dye will bind to negative structures (nucleic acids, ribosomes), and the negative dye will attach to positively charged structures (many cytoplasmic proteins). The specific mixtures, techniques and variants were named after those who developed them, e.g. Giemsa, Wright, May-Grünwald.

Category: Medicine Notes

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