The chronology of anti-malaria medicaments

• 17^th century: quinine (actually a mixture of various Cinchona-alkaloids administered in warm wine)

• 1925: Plasmoquine = Pamaquine, Praequine

• 1932: Atebrine = Mepacrine, Quinacrine

• 1934: Chloroquine (Germany, Sontochin)

• 1944: Proguanil = Paludrine®

• 1950: Pyrimethamine = Daraprim®

• 1952: Primaquine

• 1955: Amodiaquine = Flavoquine®, Camoquine®

• 1969: Artemisinin (only in China)

• 1971: Sulphadoxine/pyrimethamine = Fansidar®

• 1986: Mefloquine = Lariam®

• 1987: Artemether and Artesunate (also outside China)

• 1988: Halofantrine = Halfan®

• 1992: Atovaquone (experimental)

• 1997: Etaquine – Tafenoquine (experimental)

• 1999: Co-artemether (artemether + lumefantrine)

• 1999: Atovaquone / proguanil = Malarone® commercialised

Category: Medicine Notes