S. aureus coagulase
on
19.9.08
with
0 comments
You are here: Home » Microbiology Notes » S. aureus coagulase
in the host, prothrombin is an inactive form of thrombin; it is converted to thrombin when blood needs to coagulate
coagulase binds to human prothrombin to form staphylothrombin, which can then catalyze the reaction fibrinogen fibrin
this results in clot formation and localization of infection
furthermore, it turns out that bacteria that are coated with fibrin are less susceptible to phagocytosis
this leads to the classic presentation of Staph, which is an abscess because the coagulase-induced clot walls off the area of infection from entering lymphocytes
Category: Microbiology Notes
Subscribe to:
Post Comments (Atom)
POST COMMENT
0 comments:
Post a Comment