Iodides : Therapeutic Uses

The uses of iodide in the treatment of hyperthyroidism are in the preoperative period in preparation for thyroidectomy and, in conjunction with antithyroid drugs and propranolol, in the treatment of thyrotoxic crisis. Prior to surgery, iodide is sometimes employed alone, but more frequently it is used after the hyperthyroidism has been controlled by an antithyroid drug. It is then given during the 7 to 10 days immediately preceding the operation. Optimal control of hyperthyroidism is achieved if antithyroid drugs are first given alone. If iodine also is given from the beginning, variable responses are observed; sometimes the effect of iodide predominates, storage of hormone is promoted, and prolonged antithyroid treatment is required before the hyperthyroidism is controlled. These clinical observations may be explained by the ability of iodide to prevent the inactivation of thyroid peroxidase by antithyroid drugs

Category: Pharmacology Notes