The major inhibitors may be classified into four categories: (1) antithyroid drugs, which interfere directly with the synthesis of thyroid hormones; (2) ionic inhibitors, which block the iodide transport mechanism; (3) high concentrations of iodine itself, which decrease release of thyroid hormones from the gland and also may decrease hormone synthesis; and (4) radioactive iodine, which damages the gland with ionizing radiation. Adjuvant therapy with drugs that have no specific effects on thyroid gland hormonogenesis is useful in controlling the peripheral manifestations of thyrotoxicosis. These drugs include: inhibitors of the peripheral deiodination of thyroxine to the active hormone, triiodothyronine;
-adrenergic receptor antagonists; and Ca
2+ channel blockers.
Category:
Pharmacology Notes
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