Platinum compounds
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cisplatin is the mainstay for testicular cancer therapy
carboplatin for most solid tumors
oxaliplatin for colorectal cancer
mechanism of action
similarly to alkylators, they damage DNA; they form crosslinks
cell-cycle-independent
toxicities
cisplatin: nephrotoxicity; painful neuropathy in fingers, toes; nausea/vomiting
carboplatin has a pretty good side effect profile
oxaliplatin: neurotoxicity. ice-cold drinks lead to spasms of esophagus
Category: Pharmacology Notes
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