Microtubule inhibitors
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these all exhibit neurotoxicity because neurons depend on microtubules
vinca alkaloids block tubulin polymerization
neurotoxicity
cause necrosis if extravasated
taxanes antagonize disassembly of tubules
widely used in solid tumors
huge organic molecules that are soluble in organic agents and oils; these cause type I hypersensitivity reactions
neurotoxicity
Category: Pharmacology Notes
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