Etiology of Graves disease
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autoimmune disease where part of TSH receptor is an autoantigen
fragments of TSH-R are present on thyroid and T cell MHC complexes
then, T cells reacting to this antigen stimulate B cells and plasma cells to produce autoantibodies to TSH-R
risk factors
genetic: HLA-DR3, CTLA-4, gender
environmental: stress, smoking, high iodine intake, viral infection
thyroid-stimulating immunoglobulin is a good diagnostic tool
this helps distinguish between, say, toxic multinodular goiter and Graves disease
Category: Pathology Notes
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