Chemotherapy drugs and the cell cycle
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antimetabolites and antifolates, as well as hydroxyurea, work in S phase because they deprive the cell of things necessary for DNA synthesis
microtubule inhibitors inhibit the cell in mitosis
phase-nonspecific drugs include alkylators, platinum agents, topo II inhibitors, bleomycin
Organizing these drugs another way
about half of our drugs work by impairing DNA synthesis
the other half of the drugs work outside of DNA synthesis. these drugs (platinum agents, alkylators, topo inhibitors) damage DNA
finally, the last drugs inhibit proteins (microtubule inhibitors, -ibs, and -abs)
Category: Pharmacology Notes
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