Large Cell Carcinoma (Robbins pp 745,)
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This type of tumours probably represent SSC / adenocarcinoma, but because their cells are so undifferentiated – that they can no longer be recognised in the above category. Some of these tumour cells contain intracellular mucin, some cells are multinuclear (giant cell carcinoma), some have cleared cells (clear cell carcinoma), some have spindle shaped cells (spindle cell carcinoma).
Natural History of Lung Cancer
For a 1cm carcinoma large enough to be seen on a CXR it takes about 7.5-10yrs, given that the average time for cells to double is 3-4mths. 1cm carcinoma contains about 1 billion cells, and represents ¾ of its life time – so mostly undetectable (before it gets to 1cm).
Category: Pathology Notes
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