Autacoids Pharmacology MCQ 1 With Answer

on 22.4.08 with 0 comments



Cyclo-oxygenase-1 (COX-1) isoenzyme:

A.is increased by inflammation
B. is predominant mode of action of indomethacin best of bad lot
C. in increased by lipopolysaccharide ie G –ve endotoxin
D. is NOT involved in gastric mucosal protection tis
E. is increased by cytokines


Click Here For Answer with Discussion

The Correct option is B

Discussion
  • Option A, C & E is incorrect as Cyclo-Oxygenase -1 (COX-1) is a constitutive Enzyme.
  • Option B is correct as – Indomethacin does affect it as it’s nonselective
  • Option D is incorrect as COX-1, plays a central role in protection of the gastric mucosa , by helping in the synthesis of Prostaglandins.

Category: Pharmacology Notes

POST COMMENT

0 comments:

Post a Comment