Zaleplon & Zopiclone

on 9.3.08 with 0 comments



  • Nonbenzodiazepine agonist that acts at the GABAA1 receptors to exert actions similar to benzo’s

  • Short half-life

  • Only approx. 30% of an orally administered dose reaches the plasma, and most of that undergoes first-pass elimination

    • Half as potent as zolpidem

  • Improves sleep quality w/o rebound insomnia, and little chance of developing dependency

Category: Pharmacology Notes

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